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Nature Reviews: Neuroscience

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Updated: 8 hours 9 min ago

Neural bases of the non-conscious perception of emotional signals.

8 hours 9 min ago
Publication Date: 2010 Sep 2 PMID: 20811475
Authors: Tamietto, M. - de Gelder, B.
Journal: Nat Rev Neurosci

Many emotional stimuli are processed without being consciously perceived. Recent evidence indicates that subcortical structures have a substantial role in this processing. These structures are part of a phylogenetically ancient pathway that has specific functional properties and that interacts with cortical processes. There is now increasing evidence that non-consciously perceived emotional stimuli induce distinct neurophysiological changes and influence behaviour towards the consciously perceived world. Understanding the neural bases of the non-conscious perception of emotional signals will clarify the phylogenetic continuity of emotion systems across species and the integration of cortical and subcortical activity in the human brain.

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Neuroendocrinology: Housing conditions affect tumour growth.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803794
Authors: McCarthy, N.
Journal: Nat Rev Neurosci



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Synaptic plasticity: Assertive authorities.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803793
Authors: Wiedemann, C.
Journal: Nat Rev Neurosci



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Neuron-glia interactions: Astrocytes in the air.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803792
Authors: Welberg, L.
Journal: Nat Rev Neurosci



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Multiple sclerosis: Putting a dampener on inflammation.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803791
Authors: Kingwell, K.
Journal: Nat Rev Neurosci



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Neuron-glia interactions: A tunnel signal.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803790
Authors: Welberg, L.
Journal: Nat Rev Neurosci



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Neurodegenerative disease: microRNAs under threat from LRRK2.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803789
Authors: Wiedemann, C.
Journal: Nat Rev Neurosci



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Neurogenomics: Parental influences run deep.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803787
Authors: Bodo, C.
Journal: Nat Rev Neurosci



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Neurodegenerative disease: The missing link.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20803786
Authors: Wiedemann, C.
Journal: Nat Rev Neurosci



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Socioeconomic status and the brain: mechanistic insights from human and animal research.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20725096
Authors: Hackman, D. A. - Farah, M. J. - Meaney, M. J.
Journal: Nat Rev Neurosci

Human brain development occurs within a socioeconomic context and childhood socioeconomic status (SES) influences neural development--particularly of the systems that subserve language and executive function. Research in humans and in animal models has implicated prenatal factors, parent-child interactions and cognitive stimulation in the home environment in the effects of SES on neural development. These findings provide a unique opportunity for understanding how environmental factors can lead to individual differences in brain development, and for improving the programmes and policies that are designed to alleviate SES-related disparities in mental health and academic achievement.

MeSH Categories: Animals, Brain/*growth & development/*physiology/physiopathology, Cognition/physiology, Humans, Mental Disorders/physiopathology, *Social Class

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Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20725095
Authors: Kumar, A. - Rotter, S. - Aertsen, A.
Journal: Nat Rev Neurosci

The brain is a highly modular structure. To exploit modularity, it is necessary that spiking activity can propagate from one module to another while preserving the information it carries. Therefore, reliable propagation is one of the key properties of a candidate neural code. Surprisingly, the conditions under which spiking activity can be propagated have received comparatively little attention in the experimental literature. By contrast, several computational studies in the last decade have addressed this issue. Using feedforward networks (FFNs) as a generic network model, they have identified two dynamical activity modes that support the propagation of either asynchronous (rate code) or synchronous (temporal code) spiking. Here, we review the dichotomy of asynchronous and synchronous propagation in FFNs, propose their integration into a single extended conceptual framework and suggest experimental strategies to test our hypothesis.

MeSH Categories: *Action Potentials, Animals, Humans, *Neural Networks (Computer), Neural Pathways/physiology, Neurons/*physiology

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The neurobiology of psychedelic drugs: implications for the treatment of mood disorders.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20717121
Authors: Vollenweider, F. X. - Kometer, M.
Journal: Nat Rev Neurosci

After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders. These findings raise the possibility that research into psychedelics might identify novel therapeutic mechanisms and approaches that are based on glutamate-driven neuroplasticity.

MeSH Categories: Animals, Brain/*drug effects, Hallucinogens/*pharmacology/therapeutic use, Humans, Models, Neurological, Mood Disorders/drug therapy

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Central mechanisms of odour object perception.

8 hours 9 min ago
Publication Date: 2010 Sep PMID: 20700142
Authors: Gottfried, J. A.
Journal: Nat Rev Neurosci

The stimulus complexity of naturally occurring odours presents unique challenges for central nervous systems that are aiming to internalize the external olfactory landscape. One mechanism by which the brain encodes perceptual representations of behaviourally relevant smells is through the synthesis of different olfactory inputs into a unified perceptual experience--an odour object. Recent evidence indicates that the identification, categorization and discrimination of olfactory stimuli rely on the formation and modulation of odour objects in the piriform cortex. Convergent findings from human and rodent models suggest that distributed piriform ensemble patterns of olfactory qualities and categories are crucial for maintaining the perceptual constancy of ecologically inconstant stimuli.

MeSH Categories: Animals, Brain/anatomy & histology/*physiology, Discrimination (Psychology)/physiology, Humans, Odors, Olfactory Pathways/anatomy & histology/physiology, Olfactory Perception/*physiology, Pattern Recognition, Physiological/physiology

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